Effective English communication remains a significant challenge for non-English major students at many Vietnamese universities, often hindering their academic and professional development. This study explores the key difficulties faced by non-English majors at Thu Dau Mot University in English communication and their engagement in classroom speaking activities. Using a mixed-methods approach, the study collected data from 100 students through questionnaires and interviews. The findings reveal four primary challenges: limited vocabulary, pronunciation difficulties, overreliance on the native language, and lack of confidence. These issues not only affect students’ ability to express themselves in English but also reduce their participation in classroom activities. Despite these obstacles, the study found that active engagement in speaking activities positively impacts students’ learning outcomes, highlighting the importance of supportive and interactive teaching methods. Engagement varied, with students demonstrating greater participation in structured activities than in spontaneous speaking tasks. Based on the findings, the study provides recommendations for fostering a more engaging and effective learning environment.