Phyllanthus (Euphorbiaceae) is widely distributed in tropical and subtropical areas, including Vietnam, where it is considered a valuable medicinal herb. Numerous bioactive compounds from Phyllanthus species have been identified, demonstrating pharmacological effects such as antiallergic, anti-inflammatory, antioxidant, antidiabetic, anticancer, antiviral, antibacterial, antimalarial, and wound healing activities. This review provides a comprehensive summary of Phyllanthus genus and its pharmaceutical properties, emphasizing the methodologies used for bioactive compound extraction and evaluation, as well as their clinical relevance.