Ficus hispida L.f. (FH) is among the widely cultivated tree species in Asian regions. The aim of this work was to determine phenolic and flavonoid contents, antioxidant, in vitro anti-inflammatory activities of FH extracts prepared with methanol (ME), ethanol (ET) and ethyl acetate (EA). The extract obtained from ethyl acetate contained the highest total phenolic and flavonoid contents (92.75 +/- 5.14 mg GAE/g and 5.67 +/- 0.65 mg QE/g), followed by ME and ET. The capacity to scavenge ABTS free radical of the extracts followed the order: EA > ME > ET while their DPPH activity differed insignificantly. The inhibitory effect of EA and ME (IC¬50 = 362.84 +/- 29.05 and 386.95 +/- 11.10 ug/mL, respectively) were higher than that of ET. Correlation analysis showed a high positive correlation between total phenolic content and ABTS activity. The findings of the study would be useful for development of new nature-derived agents for prevention and treatment of diseases.