Objectives: This study investigated the relationship between work environment and job satisfaction among nurses in selected hospitals in Vietnam to propose a framework for improving nursing practice. Methods: A descriptive correlational research design was used and 375 nurses were randomly selected. Data were collected using validated instruments: the Nursing Work Index Practice Environment Scale and the Job Satisfaction Survey. Data analysis was performed using the Statistical Package for Social Sciences (SPSS) software. Descriptive statistics were used to measure the variables. Differences in work environment and job satisfaction were examined according to demographic data using independent sample t-tests and one-way ANOVA. Results: The results showed that the work environment was scored as 2.64 (SD = .42) and the job satisfaction was scored as 3.52 (SD = .47). The work environment was highly correlated with job satisfaction (r = .52, p < .01). Furthermore, long working hours in a week can lead to decreased job satisfaction among employees. Conclusion: These results indicate that the work environment is one of the key factors affecting job satisfaction. This study underscores the need for creating a supportive work environment in hospitals to enhance quality nursing care.