This study examines the use of Role-play in teaching business culture. The participants are 105 senior English majors at Thu Dau Mot University in Vietnam in the first semester of the 2024-2025 school year. This study investigates the perception of senior English majors toward the advantages and disadvantages of Role-play in the business culture courses and collects suggestions to improve this activity. One Questionnaire of Role-play is conducted at the end of the course to record the students’ overall perceptions and suggestions towards the application of Role-play during their study. The results of the Questionnaire show that the students are strongly interested in the use of Role-play during their course.